![]() Another member of the Salk lab signed the notes, too, for posterity. If cells could create proteins from mRNA delivered into them, he wrote on 11 January 1988, it might be possible to “treat RNA as a drug”. Realizing that this discovery might have far-reaching potential in medicine, Malone, a graduate student at the Salk Institute for Biological Studies in La Jolla, California, later jotted down some notes, which he signed and dated. Human cells bathed in this genetic gumbo absorbed the mRNA, and began producing proteins from it 1. He mixed strands of messenger RNA with droplets of fat, to create a kind of molecular stew. In late 1987, Robert Malone performed a landmark experiment. The RNA sequence used in the COVID-19 vaccine developed by Pfizer and BioNTech (Ψ is a modified form of the uridine nucleotide, U).
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